Adjunctive d-serine treatment for major depressive disorder: A randomized clinical trial
While d-serine did not show superior efficacy over placebo in the overall sample, it demonstrated potential as an adjunctive treatment in patients with severe MDD, particularly those receiving higher medication doses. These findings suggest that d-serine may provide synergistic benefits when combined with standard treatments in specific subgroups of patients with MDD. Trial Registration at ClinicalTrials.gov Identifier: NCT04721249.
Authors
- Anna-Chiara Schaub (ORCID: https://orcid.org/0000-0003-1931-343X)
- Undine E. Lang (ORCID: https://orcid.org/0000-0002-3585-6533)
- Philipp Sterzer (ORCID: https://orcid.org/0000-0003-4687-2317)
- André Schmidt (ORCID: https://orcid.org/0000-0001-6055-8397)
- Annette Beatrix Brühl (ORCID: https://orcid.org/0000-0003-4704-4986)
- Lukas Sempach (ORCID: https://orcid.org/0009-0000-7785-0052)
Institutions
- University of Basel (CH)
- Department of Biomedicine Basel (CH)
- Universitäre Psychiatrische Kliniken Basel (CH)
Publication Details
- Journal
- Journal of Affective Disorders
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1016/j.jad.2025.119504
- Citations
- 2
- Primary Topic
- Amino Acid Enzymes and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.22