Genetically distinct hantaviruses in two bat species in Panamá
Recent discoveries of hantaviruses in bats in Europe, Asia, and Africa have prompted expanded explorations of their host diversity and geographic distribution. In screening lung tissue of 218 bats from Panamá, representing 19 genera and five families, we detected hantavirus RNA in two of three greater sac-winged bats (Emballonuridae: <i>Saccopteryx bilineata</i>) and in four of 29 Seba's short-tailed bats (Phyllostomidae: <i>Carollia perspicillata</i>). Phylogenetic analyses of the small, medium, and large genomic segments revealed a newfound hantavirus in <i>S. bilineata</i>, tentatively designated Filo del Tallo virus, and the recently reported Buritiense virus in <i>C. perspicillata</i>. Both share common ancestry with bat-associated hantaviruses in Asia and Africa. These results indicate that bats serve as hosts of hantaviruses in the Americas. Given opportunities for close contact between humans and bats, studies on the genetic diversity, pathogenicity, and circulation dynamics of hantaviruses are urgently needed.
Authors
- Satoru Arai (ORCID: https://orcid.org/0000-0001-5865-0717)
- Jocelyn P. Colella (ORCID: https://orcid.org/0000-0003-2463-1029)
- Joseph A. Cook (ORCID: https://orcid.org/0000-0003-3985-0670)
- Carlos Carrión Bonilla (ORCID: https://orcid.org/0000-0002-8794-0008)
- Stephen E. Greiman (ORCID: https://orcid.org/0000-0003-0654-8977)
- Blas Armién (ORCID: https://orcid.org/0000-0002-8378-006X)
- Motoi Suzuki (ORCID: https://orcid.org/0000-0002-8340-0880)
- Danielle M. Land (ORCID: https://orcid.org/0009-0004-4979-1728)
- Fuka Kikuchi (ORCID: https://orcid.org/0000-0003-1815-7113)
- Jonathan L. Dunnum (ORCID: https://orcid.org/0000-0001-7868-3719)
- Ken Maeda (ORCID: https://orcid.org/0000-0002-3488-5439)
- Richard Yanagihara
- Tetsuya Mizutani (ORCID: https://orcid.org/0000-0003-2570-0452)
- Karen Yamada
- Pablo Gutiérrez-Moreno
- Mihail Pérez-Callejas
Institutions
- University of Hawaiʻi at Mānoa (US)
- Instituto Conmemorativo Gorgas de Estudios de la Salud (PA)
- University of Kansas (US)
- Tokyo University of Science (JP)
- University of New Mexico (US)
- Georgia Southern University (US)
- National Institute of Infectious Diseases (JP)
- Secretaría Nacional de Ciencia, Tecnología e Innovación (PA)
- Tokyo University of Agriculture and Technology (JP)
Publication Details
- Journal
- iScience
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1016/j.isci.2025.112749
- Citations
- 2
- Primary Topic
- Viral Infections and Vectors
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- Japan Agency for Medical Research and Development
- U.S. Army Medical Department Center and School, Health Readiness Center of Excellence