Mechanism of Dihydroartemisinin in activating macrophages to enhance host resistance to malaria
The activation of NLRP12 induced by DHA is crucial for M1 macrophage polarization, which plays a significant role in the clearance of Plasmodium parasites.
Authors
- Xiaoyu Sang (ORCID: https://orcid.org/0000-0001-8482-5146)
- Qilong Li (ORCID: https://orcid.org/0000-0002-8645-3566)
- Kexin Zheng (ORCID: https://orcid.org/0000-0002-4863-6142)
- Ning Jiang (ORCID: https://orcid.org/0000-0003-0240-2233)
- Xin Li (ORCID: https://orcid.org/0000-0002-3743-3964)
- Ran Chen (ORCID: https://orcid.org/0000-0002-5655-8527)
- Yiwei Zhang (ORCID: https://orcid.org/0000-0003-2411-5219)
- Qijun Chen (ORCID: https://orcid.org/0000-0003-0356-7435)
- Ying Feng
Institutions
- Shenyang Agricultural University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1016/j.phymed.2025.156913
- Citations
- 1
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- National Natural Science Foundation of China
- Chinese Academy of Medical Sciences Initiative for Innovative Medicine