Lipidomics Unveils Critical Lipid Pathway Shifts in Alport Syndrome
These findings demonstrate that AS involves distinct lipidomic disruptions and underscore shared lipotoxic mechanisms with DKD. This improved understanding of disease-specific lipid imbalances provides new potential therapeutic targets to mitigate podocyte injury and slow progression of AS.
Authors
- Borja Lanzón (ORCID: https://orcid.org/0000-0001-9907-4496)
- A Tato (ORCID: https://orcid.org/0000-0003-4651-0615)
- Amir Shabaka (ORCID: https://orcid.org/0000-0001-7039-4701)
- Carolina González-Riaño (ORCID: https://orcid.org/0000-0001-7026-8684)
- Teresa Bada-Bosch
- Sara Martı́nez-Martı́nez (ORCID: https://orcid.org/0000-0003-0973-3406)
- Gema Fernández‐Juárez (ORCID: https://orcid.org/0000-0001-6641-7763)
- Gema Medina‐Gómez (ORCID: https://orcid.org/0000-0001-8169-681X)
- Ángel Sevillano (ORCID: https://orcid.org/0000-0001-9063-7037)
- Coral Barbas (ORCID: https://orcid.org/0000-0003-4722-491X)
- Belén Requena (ORCID: https://orcid.org/0000-0003-4710-0685)
- Isabel Galán (ORCID: https://orcid.org/0000-0001-6031-4982)
Institutions
- Universidad San Pablo CEU (ES)
- Universidad Rey Juan Carlos (ES)
- Hospital Universitario La Paz (ES)
- Hospital Universitario de Torrejón (ES)
- Hospital Universitario Fundación Alcorcón (ES)
- Hospital Universitario 12 De Octubre (ES)
- Hospital Reina Sofía de Murcia (ES)
Publication Details
- Journal
- Kidney International Reports
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1016/j.ekir.2025.05.034
- Citations
- 2
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 3.24
Funders
- Ministerio de Ciencia, Innovación y Universidades
- Sociedad Española de Nefrología
- European Commission
- Ministerio de Ciencia e Innovación
- Instituto de Salud Carlos III
- European Regional Development Fund
- FP7 Coordination of Research Activities