Ingestion of mast cell granules boosts macrophages and drives atypical programming

MCs enhance the function of macrophages and drive them to atypical polarization through granule-mediated intercellular communication. Our results suggest that beyond acute inflammation, MCs act as important controllers of host defense and integrity, supporting their emerging relevance as therapeutic targets.

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Publication Details

Journal
Journal of Allergy and Clinical Immunology
Published
2025-05-26
DOI
https://doi.org/10.1016/j.jaci.2025.04.035
Primary Topic
Mast cells and histamine
Type
article
Field-Weighted Citation Impact
0.00

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Ingestion of mast cell granules boosts macrophages and drives atypical programming

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Ingestion of mast cell granules boosts macrophages and drives atypical programming

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article en

Abstract

MCs enhance the function of macrophages and drive them to atypical polarization through granule-mediated intercellular communication. Our results suggest that beyond acute inflammation, MCs act as important controllers of host defense and integrity, supporting their emerging relevance as therapeutic targets.

Journal of Allergy and Clinical ImmunologyVol. 156(3)
Fraunhofer Institute for Translational Medicine and Pharmacology (DE), Helmholtz Centre for Infection Research (DE), Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) (DE), Max Planck Institute of Immunobiology and Epigenetics (DE), Otto-von-Guericke-Universität Magdeburg (DE)
Deutsche Forschungsgemeinschaft, Else Kröner-Fresenius-Stiftung
Zero hunger
Openalex Percentile: Top 87%
Mast cells and histamine
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