Theophylline can resolve refractory acute negative-pressure hydrocephalus: illustrative case
Theophylline, a methylxanthine derivate used for obstructive pulmonary disease, can raise ICP in intracranial hypotension. The authors present the first successful case of theophylline for the treatment of refractory acute negative-pressure hydrocephalus. Further studies are warranted to explore the safety and efficacy of theophylline for negative-pressure hydrocephalus. https://thejns.org/doi/10.3171/CASE2554.
Authors
- Miguel Quintero‐Consuegra (ORCID: https://orcid.org/0000-0002-2190-1823)
- Enrique Vargas (ORCID: https://orcid.org/0000-0003-2974-5359)
- Robin Babadjouni (ORCID: https://orcid.org/0000-0002-5048-9233)
- Adam N. Mamelak (ORCID: https://orcid.org/0000-0002-4245-6431)
- Megan V. Ryan (ORCID: https://orcid.org/0000-0001-6712-8701)
- Catherine Garcia
- Serena Wong (ORCID: https://orcid.org/0000-0002-7837-6468)
- Shafkat Salam
- Maryam Rejali
Institutions
- Rocky Vista University (US)
- Cedars-Sinai Medical Center (US)
Publication Details
- Journal
- Journal of Neurosurgery Case Lessons
- Published
- 2025-05-26
- DOI
- https://doi.org/10.3171/case2554
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00