Protein co-aggregates of dense core amyloid plaques and CSF differ in rapidly progressive Alzheimer’s disease and slower sporadic Alzheimer’s disease
These results support a distinct immune-related proteomic profile in both the brain and the CSF that can be explored as potential biomarkers in the future for the clinical diagnosis of rpAD.
Authors
- Masaru Miyagi (ORCID: https://orcid.org/0000-0003-4325-1216)
- Gürkan Bebek (ORCID: https://orcid.org/0000-0003-3081-3371)
- James B. Leverenz (ORCID: https://orcid.org/0000-0002-0896-0749)
- Jagan A. Pillai (ORCID: https://orcid.org/0000-0001-6784-824X)
- Brian S. Appleby (ORCID: https://orcid.org/0000-0003-2275-3292)
- Xinglong Wang (ORCID: https://orcid.org/0000-0001-8657-0159)
Institutions
- University of Arizona (US)
- University Hospitals of Cleveland (US)
- Lou Ruvo Brain Institute (US)
- University Hospitals Cleveland Medical Center (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1186/s13195-025-01767-x
- Citations
- 2
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- U.S. Department of Defense
- Alzheimer's Association
- Demensförbundet
- National Institutes of Health
- Centers for Disease Control and Prevention
- National Institute on Aging