Yinzhihuang Oral Liquid Alleviates Intrahepatic Cholestasis of Pregnancy: Integrated Bioinformatics and Experimental Mechanistic Insight
This study systematically explored the active components and potential targets of YZH in ICP through network pharmacology, proteomics, and in vitro validation. The findings suggest that YZH may act via the PPAR signaling pathway by modulating genes such as <i>PPARA, PPARG, ADIPOQ</i>, and <i>APOA2</i>.
Authors
- Xuan Zhuang (ORCID: https://orcid.org/0000-0002-1919-9764)
- Weijian Zeng
- Wei Gu (ORCID: https://orcid.org/0000-0003-4978-1947)
- Ting Liu (ORCID: https://orcid.org/0000-0003-1816-5551)
- Wei Liu (ORCID: https://orcid.org/0000-0001-8245-8645)
- Jin Zhang (ORCID: https://orcid.org/0000-0001-9253-8331)
Institutions
- Shanghai Jiao Tong University (CN)
- International Peace Maternity & Child Health Hospital (CN)
- Hongzhiwei Technology (China) (CN)
Publication Details
- Journal
- Maternal-Fetal Medicine
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1097/fm9.0000000000000292
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00