Cucurbitacin B induces oral squamous cell carcinomapyroptosis via GSDME and inhibits tumour growth
CuB triggers OSCC pyroptosis through the STAT3/caspase-3/GSDME pathway, enhancing peritumoural CD8+ T cell infiltration and offering a novel strategy to boost tumour immunotherapy efficacy.
Authors
- Cheng Chen (ORCID: https://orcid.org/0000-0003-1053-3217)
- Rongrong Guo (ORCID: https://orcid.org/0000-0003-1345-627X)
- Jiawei Chai (ORCID: https://orcid.org/0000-0002-7732-2978)
- Wenpeng Yan
- Fang Zhang (ORCID: https://orcid.org/0000-0002-3530-3314)
- Heng Zhang (ORCID: https://orcid.org/0000-0003-4823-4167)
- Yajun Wang (ORCID: https://orcid.org/0000-0002-7557-5883)
- Xin Chen (ORCID: https://orcid.org/0000-0002-6546-9892)
- Yan Zheng (ORCID: https://orcid.org/0000-0002-6891-1252)
- Mengyuan Yang (ORCID: https://orcid.org/0009-0005-2342-0993)
Institutions
- Shanxi Medical University (CN)
- China Medical University (TW)
Publication Details
- Journal
- Translational Oncology
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1016/j.tranon.2025.102422
- Citations
- 4
- Primary Topic
- Cell death mechanisms and regulation
- Type
- article
- Field-Weighted Citation Impact
- 3.22