Tumour-associated macrophage infiltration differs in meningioma genotypes, and is important in tumour dynamics
These findings suggest that 3D co-culture models offer an excellent system for studying the role of immune cells, specifically TAMs, in meningioma progression. By providing a more accurate representation of the TME, these models can help identify novel immunotherapy strategies aimed at modulating the immune response within meningiomas. Ultimately, this approach may improve therapeutic outcomes and quality of life for patients with meningioma by enhancing the effectiveness of existing treatments or by offering new immunotherapeutic options.
Authors
- Emanuela Ercolano (ORCID: https://orcid.org/0000-0001-7471-9374)
- Claire Adams (ORCID: https://orcid.org/0000-0003-3871-9267)
- György Fejér
- C. Oliver Hanemann (ORCID: https://orcid.org/0000-0002-1951-1025)
- Felix Sahm (ORCID: https://orcid.org/0000-0001-5441-1962)
- Juri Na (ORCID: https://orcid.org/0000-0002-1992-0961)
- Ting Zhang (ORCID: https://orcid.org/0000-0001-5150-3992)
- Jonathan Cutajar
Institutions
- Jiangnan University (CN)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Derriford Hospital (GB)
- Wuxi Fourth People's Hospital (CN)
- University Hospitals Plymouth NHS Trust (GB)
- Peninsula College of Medicine and Dentistry (GB)
- University of Plymouth (GB)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1186/s13046-025-03419-2
- Citations
- 4
- Primary Topic
- Meningioma and schwannoma management
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- Brain Tumour Research