Assessment of increased opening pressure in patients with multiple sclerosis and aquaporin-4-IgG-positive neuromyelitis optica spectrum disorder

Increased intracranial pressure (ICP) is increasingly recognized in myelin oligodendrocyte glycoprotein antibody-associated disease but has not been systematically explored in other demyelinating conditions. This cross-sectional study examines the features of raised ICP in aquaporin-4-IgG-positive neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS). Lumbar puncture opening pressure (OP) done within 30 days of an attack was identified in 41 NMOSD patients and 37 MS patients. Raised OP was present in 7 (17.1%) NMOSD patients and 4 (10.8%) MS patients who were largely asymptomatic, partially explained by obesity, and did not require ICP lowering medications beyond acute treatment with corticosteroids.

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Publication Details

Journal
Multiple Sclerosis Journal
Published
2025-05-26
DOI
https://doi.org/10.1177/13524585251340841
Citations
1
Primary Topic
Multiple Sclerosis Research Studies
Type
article
Field-Weighted Citation Impact
1.47
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article

Assessment of increased opening pressure in patients with multiple sclerosis and aquaporin-4-IgG-positive neuromyelitis optica spectrum disorder

Natthapon Rattanathamsakul, Laura Cacciaguerra, Eoin P. Flanagan, Deena Tajfirouz et al.
1 citations
Multiple Sclerosis Journal
Multiple Sclerosis Research Studies
1.47
article

Assessment of increased opening pressure in patients with multiple sclerosis and aquaporin-4-IgG-positive neuromyelitis optica spectrum disorder

Natthapon Rattanathamsakul, Laura Cacciaguerra, Eoin P. Flanagan, Deena Tajfirouz, Nanthaya Tisavipat, Kevin D. Chodnicki, John Jing-Wei Chen, Mason G. Quick, Jan‐Mendelt Tillema, Sydney Roston
article en
1 citations

Abstract

Increased intracranial pressure (ICP) is increasingly recognized in myelin oligodendrocyte glycoprotein antibody-associated disease but has not been systematically explored in other demyelinating conditions. This cross-sectional study examines the features of raised ICP in aquaporin-4-IgG-positive neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS). Lumbar puncture opening pressure (OP) done within 30 days of an attack was identified in 41 NMOSD patients and 37 MS patients. Raised OP was present in 7 (17.1%) NMOSD patients and 4 (10.8%) MS patients who were largely asymptomatic, partially explained by obesity, and did not require ICP lowering medications beyond acute treatment with corticosteroids.

Multiple Sclerosis JournalVol. 31(10)
University of Minnesota (US), Mayo Clinic (US), Twin Cities Orthopedics (US), Mayo Clinic in Arizona (US)
Good health and well-being
Openalex Percentile: Top 19%
Multiple Sclerosis Research Studies
1.47
DOISourceOpenAlex
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Assessment of increased opening pressure in patients with multiple sclerosis and aquaporin-4-IgG-positive neuromyelitis optica spectrum disorder — Natthapon Rattanathamsakul, Laura Cacciaguerra, et al. · Multiple Sclerosis Journal (2025) | TGRS Research Map | TGRS