Photo- and Copper-Catalyzed Enantioselective Oxidation of Benzylic C(sp<sup>3</sup>)–H Bonds
Here, we report a photo- and copper-catalyzed enantioselective oxidation of benzylic C(sp<sup>3</sup>)-H bonds using <i>N</i>-hydroxyphthalimide as the oxygenated reagent. The reaction proceeds under mild conditions and does not require excess substrates or oxidants. The oxidation products can be readily transformed into chiral benzylic alcohols or hydroxylamines. Preliminary mechanism studies suggest that the oxidation reaction proceeds via a free radical mechanism.
Authors
- Ling Dai
- Li‐Jun Xiao (ORCID: https://orcid.org/0000-0002-3998-3628)
- Qi‐Lin Zhou (ORCID: https://orcid.org/0000-0002-4700-3765)
- Jia‐Bin Pan
- Xianming Liu (ORCID: https://orcid.org/0000-0002-2931-4332)
- Li Fu (ORCID: https://orcid.org/0000-0001-6675-2641)
- Yin Yang (ORCID: https://orcid.org/0009-0005-6855-8494)
- Chao Fan (ORCID: https://orcid.org/0000-0002-6981-7292)
Institutions
- Nankai University (CN)
Publication Details
- Journal
- Journal of the American Chemical Society
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1021/jacs.5c04142
- Citations
- 10
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 9.36