Gut-derived serotonin as a molecular mediator of gravity management

This article advances a novel hypothesis that serotonin, especially gut-derived serotonin, acts as a gravity management substance, helping the body adapt to gravitational forces through its systemic effects.Produced predominantly in the gut and released into circulation via blood platelets, serotonin influences vascular tone, baroreceptor function, upward lymphatic flow, muscle readiness, and proprioception, collectively contributing to postural stability and cardiovascular regulation in a gravity-bound world.Without this critical neurohormone, we could not easily stand up, stay up, maintain balance, circulate blood, drain interstitial fluid, or pump intestinal contents in a 1g world.The gut microbiome plays a key role in serotonin synthesis, highlighting a co-evolutionary relationship that supports anti-gravity mechanisms.Disruptions in gut-derived serotonin due to microbiome dysbiosis may contribute to conditions like orthostatic intolerance, dysautonomia, postural tachycardia syndrome, irritable bowel syndrome, lymphedema, and chronic pain, among many others.Central effects of serotonin, including its role in the vestibular system, further support its involvement in managing gravity by aiding balance and spatial orientation.This perspective positions the gastrointestinal system as central to gravity adaptation, echoing Hippocrates' assertion that "all disease begins in the gut.