Pan-cancer gene signature analysis of macrophage polarization and compound prediction for reprogramming tumor-associated macrophages toward M1-like macrophages

This study provides a pan-cancer characterization of the TAM polarization-related gene profile. Network pharmacology and molecular docking analyses revealed five promising therapeutic agents for TAM reprogramming. Thus, our findings provide valuable insights into the enhancement of immune responses to inhibit tumor immune escape and metastasis.

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Publication Details

Journal
Cancer Pathogenesis and Therapy
Published
2025-05-20
DOI
https://doi.org/10.1016/j.cpt.2025.05.002
Primary Topic
Epigenetics and DNA Methylation
Type
article
Field-Weighted Citation Impact
0.00
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article

Pan-cancer gene signature analysis of macrophage polarization and compound prediction for reprogramming tumor-associated macrophages toward M1-like macrophages

Yuting Jin, Wei Zhu, Chunyan Xu, Xiaojing Liu et al.
Cancer Pathogenesis and Therapy
Epigenetics and DNA Methylation
article

Pan-cancer gene signature analysis of macrophage polarization and compound prediction for reprogramming tumor-associated macrophages toward M1-like macrophages

Yuting Jin, Wei Zhu, Chunyan Xu, Xiaojing Liu, Cheng Liu, Jing Xu
article en

Abstract

This study provides a pan-cancer characterization of the TAM polarization-related gene profile. Network pharmacology and molecular docking analyses revealed five promising therapeutic agents for TAM reprogramming. Thus, our findings provide valuable insights into the enhancement of immune responses to inhibit tumor immune escape and metastasis.

Cancer Pathogenesis and TherapyVol. 4(2)
Nanjing University of Chinese Medicine (CN), Xuzhou Medical College (CN), Yili Friendship Hospital (CN), Nanjing Drum Tower Hospital (CN), Second People’s Hospital of Huai’an (CN), Jiangsu Province Hospital (CN), Nanjing Medical University (CN)
Openalex Percentile: Top 90%
Epigenetics and DNA Methylation
DOIOpen Access PDFOpenAlex
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Pan-cancer gene signature analysis of macrophage polarization and compound prediction for reprogramming tumor-associated macrophages toward M1-like macrophages — Yuting Jin, Wei Zhu, et al. · Cancer Pathogenesis and Therapy (2025) | TGRS Research Map | TGRS