Distinct Longitudinal Clinical‐Neuroanatomical Trajectories in Parkinson's Disease Clinical Subtypes: Insight toward Precision Medicine
Longitudinal analysis revealed distinct patterns of clinical progression and regional atrophy in PD subtypes, with the diffuse-malignant subtype showing more severe neurodegeneration and clinical deterioration suggesting existence of diverse pathophysiological mechanisms in PD. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Authors
- Anthony E. Lang (ORCID: https://orcid.org/0000-0003-1229-3667)
- Yashar Zeighami (ORCID: https://orcid.org/0000-0002-0583-5811)
- Ronald B. Postuma (ORCID: https://orcid.org/0000-0002-6468-4734)
- Seyed‐Mohammad Fereshtehnejad (ORCID: https://orcid.org/0000-0001-9255-9351)
- Roqaie Moqadam (ORCID: https://orcid.org/0000-0003-0361-3083)
- Mahsa Dadar (ORCID: https://orcid.org/0000-0003-4008-2672)
- Connie Marras
- Houman Azizi (ORCID: https://orcid.org/0009-0001-3593-5231)
Institutions
- Montreal Neurological Institute and Hospital (CA)
- University of Toronto (CA)
- Toronto Western Hospital (CA)
- Douglas Mental Health University Institute (CA)
- Karolinska Institutet (SE)
- McGill University (CA)
Publication Details
- Journal
- Movement Disorders
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1002/mds.30229
- Citations
- 11
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 15.28
Funders
- Parkinson Canada
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
- Fonds de Recherche du Québec - Santé