Fibroblast reprogramming in the dura mater of NTG-induced migraine-related chronic hypersensitivity model drives monocyte infiltration via Angptl1-dependent stromal signaling
Our study reveals that NTG reprograms meningeal fibroblasts to expand a pro-inflammatory fibroblast subtype, which drives migraine-related chronic hypersensitivity through TNF-α/NF-κB signaling and Angptl1-mediated monocyte crosstalk. The identified Mafk-Angptl1 axis presents a potential therapeutic target, though human validation remains essential.
Authors
- Wei Wang (ORCID: https://orcid.org/0000-0003-2302-6273)
- Rui Zhao (ORCID: https://orcid.org/0000-0003-3769-6550)
- Lei Zhang (ORCID: https://orcid.org/0000-0003-3600-9413)
- Xuyang Liu (ORCID: https://orcid.org/0000-0001-5802-4169)
- Peiyu Wu (ORCID: https://orcid.org/0000-0003-1563-5925)
- Yiping Deng
- Guangyu Guo (ORCID: https://orcid.org/0000-0003-3079-8474)
Institutions
- Sir Run Run Shaw Hospital (CN)
- Zhengzhou University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- The Journal of Headache and Pain
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1186/s10194-025-02058-4
- Citations
- 4
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.88
Funders
- Sir Run Run Shaw Hospital
- Zhejiang University