Uncovering codon usage patterns during murine embryogenesis and tissue-specific developmental diseases
These techniques identified relative synonymous codon usage differences/similarities among strains and deviations in codon usage patterns between healthy and disease-linked genes. Original transcriptomic mouse data and RefSeq gene sequences can be found at the associated Mouse Embryo CoCoPUTs (codon and codon pair usage tables) website. Future studies can leverage this resource to uncover further insights into the dynamics of embryonic development and the corresponding codon usage biases that are paramount to understanding disease processes of embryologic origin.
Authors
- Rahul Paul (ORCID: https://orcid.org/0000-0002-9662-9449)
- Anton A. Komar (ORCID: https://orcid.org/0000-0003-4188-0633)
- Luis V. Santana‐Quintero (ORCID: https://orcid.org/0000-0002-4290-1021)
- Chava Kimchi‐Sarfaty (ORCID: https://orcid.org/0000-0002-9355-8585)
- Brian Lin (ORCID: https://orcid.org/0000-0003-2944-3051)
- Anton Golikov
- Sean Smith (ORCID: https://orcid.org/0000-0001-6758-4037)
- Ryan Hunt (ORCID: https://orcid.org/0000-0003-1418-9919)
- Haim Bar (ORCID: https://orcid.org/0000-0002-5496-9699)
- Juan C. Ibla (ORCID: https://orcid.org/0000-0003-2096-5363)
- Michael DiCuccio (ORCID: https://orcid.org/0000-0003-0585-2862)
- Sarah E Fumagalli (ORCID: https://orcid.org/0000-0003-2469-4476)
- Collin Campbell
Institutions
- Cleveland State University (US)
- Boston Children's Hospital (US)
- Center for Biologics Evaluation and Research (US)
- Harvard University (US)
- University of Connecticut (US)
- Applied Research (United States) (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-05-26
- DOI
- https://doi.org/10.3389/fgene.2025.1554773
- Citations
- 1
- Primary Topic
- RNA and protein synthesis mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.81