Over-activation and dysfunction of platelet-NK cell aggregates in HIV-infected individuals
Our study indicates that platelet-NK cell aggregates exhibit characteristics of over-activation and dysfunction during HIV-1 infection. Hyperactivated platelets and the formation of platelet-NK cell aggregates contribute to the HIV-1 disease progression and the inflammation of the immune system. These findings may implicate potential targets of overactivated platelets for HIV-1 disease progression.
Authors
- Meiqing Jiang
- Jiantao Fu (ORCID: https://orcid.org/0000-0002-7039-1807)
- Meiju Deng
- Juan Du (ORCID: https://orcid.org/0000-0001-6199-0157)
- Hongxin Zhao (ORCID: https://orcid.org/0000-0002-7856-2877)
- Ruojia Biao
Institutions
- Capital Medical University (CN)
- National Institute for Communicable Disease Control and Prevention (CN)
- Beijing Ditan Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1186/s12967-025-06591-3
- Citations
- 1
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- National Natural Science Foundation of China
- Beijing Municipal Health Commission
- Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support
- Beijing Municipal Administration of Hospitals