Demographic characteristics and disease severity associated with IgA/IgG deposition patterns in autoimmune bullous diseases: a cohort study based on a registry database
Female gender, stronger IgG deposition, and mucosa tissue are key factors affecting IgA and IgG co-deposition in AIBD patients. For clinical correlation, patients with IgA and IgG co-deposition in pemphigus exhibit more severe disease severity compared with those with IgG deposition only, while patients with co-deposition in pemphigoid are more prone to mucosal involvement.
Authors
- Jiyun Pang
- Yuxi Zhou (ORCID: https://orcid.org/0000-0002-9231-2794)
- Mei Yang (ORCID: https://orcid.org/0000-0003-0507-5776)
- Hongxiang Hu (ORCID: https://orcid.org/0000-0002-6221-7462)
- Mi Wang (ORCID: https://orcid.org/0009-0009-6851-5944)
- Xiwen Zhang
- Weidong Li (ORCID: https://orcid.org/0000-0003-0521-7412)
- Jiong Li (ORCID: https://orcid.org/0000-0003-1125-026X)
- Yue Xiao (ORCID: https://orcid.org/0000-0002-5629-7638)
- Weiyu Yan
- Xingli Zhou (ORCID: https://orcid.org/0000-0001-7060-254X)
- Xun Feng
- Min Zou (ORCID: https://orcid.org/0009-0003-7116-5152)
- Hongjie Liu
- Yazan Moufaq Alqusseireen
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-26
- DOI
- https://doi.org/10.3389/fimmu.2025.1565073
- Primary Topic
- Autoimmune Bullous Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Sichuan Province