Genetic association of ACE2 rs2285666 (C>T) and rs2106809 (A>G) and susceptibility to SARS-CoV-2 infection among the Ghanaian population
This study found no association between ACE2 rs2106809 genetic variant and susceptibility to SARS-CoV-2 infection, whilst the rs2285666 T-allele was associated with a decreased frequency for SARS-CoV-2 infection among Ghanaian females. These findings enhance our understanding of genetic factors influencing SARS-CoV-2 susceptibility, which could help identify at-risk populations and inform more targeted public health interventions in future outbreaks.
Authors
- Christian Obirikorang (ORCID: https://orcid.org/0000-0002-6128-1358)
- Evans Asamoah Adu (ORCID: https://orcid.org/0000-0001-6374-0979)
- Nicole S. Struck (ORCID: https://orcid.org/0000-0002-4753-5841)
- Susan E Newton
- Eva Lorenz (ORCID: https://orcid.org/0000-0002-6057-0078)
- Alfred Edwin Yawson (ORCID: https://orcid.org/0000-0001-6960-5751)
- John Amuasi (ORCID: https://orcid.org/0000-0002-8640-2662)
- Ebenezer Oduro‐Mensah (ORCID: https://orcid.org/0000-0002-8888-3439)
- Jenny Kettenbeil (ORCID: https://orcid.org/0000-0002-4571-7545)
- Rose Odotei Adjei (ORCID: https://orcid.org/0000-0002-4438-6190)
- Wibke Loag (ORCID: https://orcid.org/0000-0003-4261-365X)
- Anthony Afum-Adjei Awuah (ORCID: https://orcid.org/0000-0002-8912-9673)
- Doris Winter
- Alexander Owusu Boakye (ORCID: https://orcid.org/0009-0006-1559-7673)
- Gracelyn Asare
- Aurélia Souares (ORCID: https://orcid.org/0000-0002-3984-5866)
- Yaw Adu Sarkodie
- Austin Gideon Adobasom-Anane (ORCID: https://orcid.org/0000-0003-4936-4078)
- James Deke
- Louis Adu-Amoah (ORCID: https://orcid.org/0000-0001-6755-2545)
- Stephen Apanga (ORCID: https://orcid.org/0000-0001-7108-3454)
- Nana Safi Almoustapha
- Amos Amoako-Adusei (ORCID: https://orcid.org/0000-0002-8002-463X)
- Eric Ebenezer Amprofi Boham (ORCID: https://orcid.org/0000-0002-7161-1197)
- Jürgen May (ORCID: https://orcid.org/0000-0001-7831-8420)
- Oumou Maïga‐Ascofaré (ORCID: https://orcid.org/0000-0003-2947-5651)
- Matthew Grant (ORCID: https://orcid.org/0000-0002-1334-4414)
- Hakim Alani
- Welbeck Odame Dzadey
- Sally-Ann Kroduah
Institutions
- University of Ghana (GH)
- Universität Hamburg (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Kwame Nkrumah University of Science and Technology (GH)
- University Medical Center Hamburg-Eppendorf (DE)
- German Center for Infection Research (DE)
- Kumasi Centre for Collaborative Research in Tropical Medicine (GH)
- 37 Military Hospital (GH)
- Ghana Health Service (GH)
- University for Development Studies (GH)
- Bernhard Nocht Institute for Tropical Medicine (DE)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-05-26
- DOI
- https://doi.org/10.3389/fgene.2025.1555515
- Citations
- 2
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 2.79