Fecal 16S rRNA sequencing and metabolomics reveal abnormal metabolism activity in preterm infants with different gestational ages
Significant differences were observed in the fecal microbiome and metabolome between preterm and full-term infants, particularly in those born before 32 weeks of gestation. These findings suggested that the gut microbial system in preterm infants undergone progressive maturation, approaching a "healthy" state characteristic of full-term infants as gestational age increases.
Authors
- Benqing Wu (ORCID: https://orcid.org/0000-0001-5015-8074)
- Jincheng Dai
- Xiangsheng Cai (ORCID: https://orcid.org/0000-0002-6353-8188)
- Liang Guo (ORCID: https://orcid.org/0000-0002-1954-1179)
- Ling Liu (ORCID: https://orcid.org/0000-0001-9343-1018)
Institutions
- Guangdong Medical College (CN)
- ShenZhen People’s Hospital (CN)
- Twelfth Guangzhou City People's Hospital (CN)
- Shenzhen Bao'an District People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-05-26
- DOI
- https://doi.org/10.3389/fcimb.2025.1530653
- Primary Topic
- Infant Nutrition and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Guangdong Medical Research Foundation