Chloroquine induces eryptosis in P. falciparum-infected red blood cells and the release of extracellular vesicles with a unique protein profile
These findings provide new insights into a novel drug-induced cell death mechanism that targets the parasite and specific components of the infected host RBC.
Authors
- Harshvardhan Modh (ORCID: https://orcid.org/0000-0001-7651-337X)
- Claudia Carrera-Bravo (ORCID: https://orcid.org/0000-0003-3566-9022)
- Kevin S. W. Tan (ORCID: https://orcid.org/0000-0001-9022-729X)
- Jing Wen Hang (ORCID: https://orcid.org/0000-0001-9491-4492)
- Trang T. T. Chu (ORCID: https://orcid.org/0000-0002-4943-7727)
- Matthias G. Wacker (ORCID: https://orcid.org/0000-0002-2789-6463)
- Benoît Malleret (ORCID: https://orcid.org/0000-0001-9658-7528)
- Chenyuan Huang (ORCID: https://orcid.org/0000-0002-1812-7283)
- Jiong‐Wei Wang (ORCID: https://orcid.org/0000-0001-7986-6082)
- Laurent Rénia (ORCID: https://orcid.org/0000-0003-0349-1557)
- Haining Hao
- Tianchi Zhou (ORCID: https://orcid.org/0000-0002-6530-9629)
- Sitong Zhang (ORCID: https://orcid.org/0000-0002-1613-4682)
- María José Cabada-García
Institutions
- Agency for Science, Technology and Research (SG)
- National University of Singapore (SG)
- Singapore Immunology Network (SG)
- Shandong Institute for Product Quality Inspection (CN)
- National University Health System (SG)
- Centre for Inflammation Research (GB)
- Institute of Genetics and Cancer (GB)
- Institute of Quality Standards and Testing Technology for Agro Products (CN)
- The Queen's Medical Research Institute (GB)
- Tecnológico de Monterrey (MX)
- University of Edinburgh (GB)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-05-26
- DOI
- https://doi.org/10.3389/fcimb.2025.1553123
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00