a1-antitrypsin, a new biomarker of polycystic ovary syndrome by changing its expression and rhythm
Increased A1AT levels in women with newly diagnosed PCOS were related to androgens, suggesting that A1AT might be a potential biomarker for PCOS. Serum A1AT levels exhibited a significant diurnal rhythm in the control group, while it was not diurnal in the PCOS group. These findings provide a theoretical foundation for understanding the role of the circadian clock in the prevention and treatment of PCOS in females with biorhythm disorders.
Authors
- Wei Cao (ORCID: https://orcid.org/0000-0002-8952-9159)
- Rongbo He
- Rourou Chen
- Lin Xu (ORCID: https://orcid.org/0000-0002-0537-922X)
- Beilei Shen
- Qian Li (ORCID: https://orcid.org/0000-0003-2893-3120)
- Yu Liu (ORCID: https://orcid.org/0000-0001-6012-5305)
- Na Li (ORCID: https://orcid.org/0000-0003-0958-608X)
Institutions
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Ovarian Research
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1186/s13048-025-01698-z
- Citations
- 1
- Primary Topic
- Ovarian function and disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.70
Funders
- National Key Research and Development Program of China