Identification of Grb2 protein as a potential mediator of macrophage activation in acute pancreatitis based on bioinformatics and experimental verification
Inhibition of Grb2 can effectively prevent M1 macrophage activation and alleviate AP. Grb2 may potentially be an effective target of macrophage activation for the treatment of AP.
Authors
- Weijuan Gong (ORCID: https://orcid.org/0000-0002-8543-1314)
- Guotao Lu (ORCID: https://orcid.org/0000-0002-8325-0405)
- L Wang
- Keyan Wu (ORCID: https://orcid.org/0000-0003-1635-9862)
- Yaodong Wang
- Chenchen Yuan (ORCID: https://orcid.org/0000-0002-0551-0718)
- Qinhao Shen (ORCID: https://orcid.org/0000-0001-8886-015X)
- Wei Li (ORCID: https://orcid.org/0000-0003-0236-4214)
- Shuai Wang (ORCID: https://orcid.org/0000-0003-4808-9545)
- Weiwei Chen (ORCID: https://orcid.org/0000-0003-1674-3231)
- Weixuan Yang (ORCID: https://orcid.org/0009-0004-6134-1068)
- Bo Tu (ORCID: https://orcid.org/0000-0002-7526-2588)
Institutions
- Toho University (JP)
- Xuzhou Medical College (CN)
- Fred Hutch Cancer Center (US)
- Shanghai University of Traditional Chinese Medicine (CN)
- Traditional Chinese Medicine Hospital of Kunshan (CN)
- Second People’s Hospital of Huai’an (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-26
- DOI
- https://doi.org/10.3389/fimmu.2025.1575880
- Citations
- 2
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province for Distinguished Young Scholars