Neuroprotection unveiled: melatonin mitigates apoptotic pathways in traumatic brain injury
TBI increased apoptotic protein expression, indicating neurodegeneration. The administration of melatonin at 10 mg/kg attenuated TBI-induced apoptosis and demyelination while promoting anti-apoptotic protein expression in the experimental model. These findings suggest a potential therapeutic role for melatonin in the management of TBI.
Authors
- Mehmet Yiğit Akgün (ORCID: https://orcid.org/0000-0003-1342-7663)
- Özkan Ateş (ORCID: https://orcid.org/0000-0002-3132-4839)
- Uğur Şeker (ORCID: https://orcid.org/0000-0002-1693-6378)
- İbrahim Başar (ORCID: https://orcid.org/0000-0003-3674-4864)
- Ege Anıl Uçar (ORCID: https://orcid.org/0000-0003-3672-7343)
- Sezer Onur Gunara
Institutions
- Dicle University (TR)
- Koç University (TR)
- Mardin Artuklu University (TR)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-05-26
- DOI
- https://doi.org/10.3389/fneur.2025.1551449
- Citations
- 1
- Primary Topic
- Child Abuse and Related Trauma
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- Dicle Üniversitesi