Discovery of homocamptothecin derivative TOP-0618 as a radiosensitive agent for the treatment of pancreatic cancer
Our work demonstrates the radiosensitizing effect of homocamptothecin derivative TOP-0618 on pancreatic cancer both in vivo and vitro, and lays a foundation for clinical transformation.
Authors
- Cheng-Yi Huang (ORCID: https://orcid.org/0000-0001-6686-5750)
- Huojun Zhang
- Zhenyuan Miao (ORCID: https://orcid.org/0000-0001-7839-4183)
- Liang Chen (ORCID: https://orcid.org/0000-0001-7300-6604)
- Di Chen (ORCID: https://orcid.org/0000-0002-2181-4703)
- Wenjuan Chen (ORCID: https://orcid.org/0000-0003-4361-980X)
- Yangyang Gong
- Yin Tang
- Liang You
Institutions
- Second Military Medical University (CN)
- Changhai Hospital (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-05-25
- DOI
- https://doi.org/10.1186/s12885-025-14347-x
- Primary Topic
- Cancer therapeutics and mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China