Conjugated bile acids promote metabolic dysfunction-associated steatotic liver disease through inducing nuclear translocation of sphingosine-1-phosphate receptor 2 to disrupt peroxisome proliferator-activated receptor alpha
CBAs promoted MASLD through inducing S1PR2 translocation into the nucleus, where it bound PPARα to interdict the function of PPARα in regulating genes involved in lipid catabolism.
Authors
- Yong Hai (ORCID: https://orcid.org/0000-0002-7206-325X)
- Xinfeng Wu (ORCID: https://orcid.org/0000-0002-8597-8272)
- Hui Shao (ORCID: https://orcid.org/0000-0001-7566-6921)
- Ming Tan (ORCID: https://orcid.org/0000-0001-6565-699X)
- Shu‐Xiang Cui (ORCID: https://orcid.org/0000-0002-4466-6045)
- Zhao Sun (ORCID: https://orcid.org/0000-0002-9005-5499)
- Keqin Li (ORCID: https://orcid.org/0000-0001-5224-4048)
- Xiaohui Liu (ORCID: https://orcid.org/0000-0002-9084-1684)
- Liang Wang (ORCID: https://orcid.org/0000-0002-5247-6727)
- Sheng Zhan
- Rong‐Rong Miao
- Rui‐Hua Xu (ORCID: https://orcid.org/0000-0001-9771-8534)
- Xian‐Jun Qu
- Yuyao Cheng
Institutions
- Capital Medical University (CN)
- China Rehabilitation Research Center (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-05-25
- DOI
- https://doi.org/10.1186/s12964-025-02249-1
- Citations
- 3
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- Innovative Research Group Project of the National Natural Science Foundation of China
- National Natural Science Foundation of China
- Ocean University of China