miR-196b strictly regulates and reliably predicts the response to cetuximab in colorectal cancer
This study supports that activation of the ERK signaling pathway is a key factor in cetuximab resistance. In addition, miR-196b can modulate and predict the CRC response to cetuximab, holding broad potential applications.
Authors
- Miaomiao Gou (ORCID: https://orcid.org/0000-0001-9622-1198)
- Zhao-Li Tan (ORCID: https://orcid.org/0000-0001-7600-2350)
- Yumeng Cui (ORCID: https://orcid.org/0009-0001-0287-5623)
- Yanghua Li (ORCID: https://orcid.org/0000-0001-9072-435X)
- Zhikuan Wang (ORCID: https://orcid.org/0000-0002-7025-735X)
- Fang Pang
- Weiling Man
- Shiyun Chen (ORCID: https://orcid.org/0000-0002-6224-2975)
- Ying Li (ORCID: https://orcid.org/0000-0002-2015-3560)
- Xiang Li (ORCID: https://orcid.org/0000-0002-5942-7282)
- Yanli Lin
- Xiaojie Wu
- Youliang Wang (ORCID: https://orcid.org/0000-0003-1319-0344)
- Guanghai Dai (ORCID: https://orcid.org/0000-0002-3220-9736)
- Lu Han (ORCID: https://orcid.org/0009-0007-5911-9128)
Institutions
- Nankai University (CN)
- Chinese PLA General Hospital (CN)
- Biotechnology Research Center (IR)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-05-25
- DOI
- https://doi.org/10.1186/s11658-025-00740-8
- Citations
- 1
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China