Optimizing Nortriptyline Dosing: A Comparison between Pharmacogenetics-Based, Phenotype-Based, and Standard Dosing
Pharmacogenetics-based and phenotype-based dosing demonstrate greater accuracy in predicting therapeutic nortriptyline plasma concentrations than standard dosing. Further research is warranted to explore the clinical application of model-informed precision dosing for nortriptyline and other psychotropic medications.
Authors
- Joost Janzing (ORCID: https://orcid.org/0000-0002-8409-7473)
- Rob ter Heine (ORCID: https://orcid.org/0000-0003-2185-8201)
- Sophie E. ter Hark (ORCID: https://orcid.org/0000-0001-7079-8335)
- Arnt Schellekens (ORCID: https://orcid.org/0000-0002-7715-5209)
- Cornelis F. Vos (ORCID: https://orcid.org/0000-0001-6760-1474)
- Rob E. Aarnoutse (ORCID: https://orcid.org/0000-0001-8925-969X)
- Marieke J. H. Coenen (ORCID: https://orcid.org/0000-0001-8796-2031)
Institutions
- Radboud University Nijmegen (NL)
- Radboud University Medical Center (NL)
- Parnassia Groep (NL)
- Nijmegen Institute for Scientist Practitioners in Addiction (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Clinical Pharmacokinetics
- Published
- 2025-05-25
- DOI
- https://doi.org/10.1007/s40262-025-01528-x
- Primary Topic
- Pharmacogenetics and Drug Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- ZonMw