Multimodal markers of immune activation predict cognitive outcomes in Parkinson’s disease
An increase in activated CD4 cells in the blood, transition of B cells to the CNS and inflammation in the substantia nigra were predictive of longitudinal cognitive outcomes in PD. These markers warrant further validation as biomarkers for immune/inflammatory stratification and add to the evidence supporting development of therapeutic strategies to reduce microglial inflammation or the recruitment of lymphocytes to the CNS in early PD.
Authors
- Caroline H. Williams‐Gray (ORCID: https://orcid.org/0000-0002-2648-9743)
- Antonina Kouli (ORCID: https://orcid.org/0000-0001-6553-6154)
- Tim D. Fryer (ORCID: https://orcid.org/0000-0003-1555-9790)
- Hong Yan (ORCID: https://orcid.org/0000-0003-1230-096X)
- Imtiaz H. Solim
- Marta Camacho (ORCID: https://orcid.org/0000-0002-1490-5703)
- Alexander R. D. Peattie (ORCID: https://orcid.org/0000-0003-2115-7640)
- Lennart R. B. Spindler
- Kirsten M. Scott (ORCID: https://orcid.org/0000-0003-3121-5963)
- L. Kahanawita
Institutions
- University of Cambridge (GB)
- Cambridge University Hospitals NHS Foundation Trust (GB)
Publication Details
- Journal
- Brain Behavior and Immunity
- Published
- 2025-05-25
- DOI
- https://doi.org/10.1016/j.bbi.2025.05.020
- Citations
- 2
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- UK Research and Innovation
- Guarantors of Brain
- Research Councils UK
- Evelyn Trust
- Medical Research Council
- NIHR Cambridge Biomedical Research Centre
- Cambridge Centre for Parkinson-Plus