Yangke powder alleviates OVA-induced allergic asthma by inhibiting the PI3K/AKT/NF-κB signaling pathway
This investigation identifies Kaempferol, Norephedrine, Cynaroside, Genistein, and Rutin as critical active ingredients in YKS, impacting key biomarkers such as AKT1, TNF, and IL1B. These substances effectively modulate the PI3K/AKT/NF-κB pathway, enhancing the management of allergic asthma.
Authors
- Zihan Wang (ORCID: https://orcid.org/0000-0003-3084-3634)
- Qingqing Xia (ORCID: https://orcid.org/0000-0001-5287-0639)
- Lu Ding (ORCID: https://orcid.org/0000-0001-7547-2844)
- Xiangyan Li (ORCID: https://orcid.org/0000-0001-6780-6314)
- Xiaolin Tong (ORCID: https://orcid.org/0000-0002-4400-384X)
- Daqing Zhao (ORCID: https://orcid.org/0000-0001-5678-7410)
- Siyu Song (ORCID: https://orcid.org/0000-0001-9160-3111)
- Liyuan Cao (ORCID: https://orcid.org/0000-0003-0794-3645)
- Zeyu Wang (ORCID: https://orcid.org/0000-0003-2382-6588)
- Xueyan Li (ORCID: https://orcid.org/0000-0003-2251-710X)
- Min Li (ORCID: https://orcid.org/0000-0002-0072-5912)
- Zhenghua Cao (ORCID: https://orcid.org/0009-0008-2827-9775)
- Zirui Li (ORCID: https://orcid.org/0000-0002-6679-8006)
- Kai Yin
Institutions
- Changchun University of Chinese Medicine (CN)
- The Affiliated Hospital to Changchun University of Chinese Medicine (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1186/s13020-025-01125-x
- Citations
- 6
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 6.99
Funders
- State Administration of Traditional Chinese Medicine of the People's Republic of China
- Jilin Scientific and Technological Development Program