Hazard screening of colloidal silica nanomaterials with varying degrees of silane surface functionalization: a safe-by-design case study
We show that in vitro toxicity assays provide valuable information for SSbD decision making. In vitro cytotoxic, pro-inflammatory and oxidative stress responses can be reduced with increasing surface silane functionalization. The reduced deposition efficiency with increasing silane functionalization, however, highlights that thorough characterization of particle behaviour in cell culture medium should always be performed for SSbD hazard testing. The amount of silane required to reduce toxicity is important information for the future production of safer SiO<sub>2</sub>-NFs and nano-enabled products. Exposure, functionality, and sustainability remain to be investigated to draw full SSbD conclusions.
Authors
- Marie Carrière (ORCID: https://orcid.org/0000-0001-8446-6462)
- Arnaud Guiot
- Nienke Ruijter (ORCID: https://orcid.org/0009-0002-7199-8325)
- Ilaria Zanoni (ORCID: https://orcid.org/0000-0001-8692-3460)
- Matthew Boyles (ORCID: https://orcid.org/0000-0003-4291-4903)
- Hedwig Braakhuis (ORCID: https://orcid.org/0000-0002-7677-7516)
- Alberto Katsumiti (ORCID: https://orcid.org/0000-0003-4145-4853)
- Daniel Persson (ORCID: https://orcid.org/0000-0003-0940-109X)
- Flemming R. Cassee (ORCID: https://orcid.org/0000-0001-9958-8630)
- Michael Persson (ORCID: https://orcid.org/0000-0001-8655-647X)
- Jessica Marshall
- Josje H.E. Arts
Institutions
- Institut polytechnique de Grenoble (FR)
- Centre National de la Recherche Scientifique (FR)
- Edinburgh Napier University (GB)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Laboratoire d’Innovation pour les Technologies des Énergies Nouvelles et les nanomatériaux (FR)
- CEA Grenoble (FR)
- Institut de Recherche Interdisciplinaire de Grenoble (FR)
- Laboratoire des Matériaux Avancés (FR)
- National Institute for Public Health and the Environment (NL)
- Institute of Science and Technology for Ceramics (IT)
- GAIKER Technology Centre (ES)
- Institute of Occupational Medicine (GB)
- Deventer Ziekenhuis (NL)
- Chalmers University of Technology (SE)
- Université Grenoble Alpes (FR)
Publication Details
- Journal
- Particle and Fibre Toxicology
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1186/s12989-025-00629-6
- Citations
- 1
- Primary Topic
- Chemical Safety and Risk Management
- Type
- article
- Field-Weighted Citation Impact
- 5.79
Funders
- European Commission
- Ministry of Infrastructure and Water Management
- Horizon 2020 Framework Programme
- Rijksinstituut voor Volksgezondheid en Milieu