Sex differences in amyloid PET in a large, real‐world sample from the Imaging Dementia–Evidence for Amyloid Scanning (IDEAS) Study
Females exhibited higher rates of amyloid positron emission tomography (PET) positivity and higher amyloid burden than males. These sex effects were found in patients with both mild cognitive impairment (MCI) and dementia. Females also had higher rates of dementia and amnestic MCI, while males had higher rates of non-amnestic MCI and more cholinesterase inhibitor use.
Authors
- Claire Yballa
- Renaud La Joie (ORCID: https://orcid.org/0000-0003-2581-8100)
- Daniel R. Schonhaut
- Constantine Gatsonis
- Ehud Zeltzer (ORCID: https://orcid.org/0000-0002-1146-0358)
- Barry A. Siegel (ORCID: https://orcid.org/0000-0001-6246-5792)
- Nidhi S. Mundada (ORCID: https://orcid.org/0000-0003-3108-6751)
- Jhony Mejia (ORCID: https://orcid.org/0000-0002-0313-6902)
- Karen Smith
- Gil D. Rabinovici (ORCID: https://orcid.org/0000-0002-3626-4265)
- Isabel Elaine Allen (ORCID: https://orcid.org/0000-0001-9029-9744)
- Andrew March
- Maison Abu Raya (ORCID: https://orcid.org/0000-0002-7272-2104)
- Ganna Blazhenets (ORCID: https://orcid.org/0000-0003-2419-7373)
- Leonardo Iaccarino (ORCID: https://orcid.org/0000-0003-0053-9519)
- Charles Windon (ORCID: https://orcid.org/0000-0001-8719-1206)
- Bruce E. Hillner
- Rachel A. Whitmer (ORCID: https://orcid.org/0009-0006-9511-6138)
- Lucy Hanna (ORCID: https://orcid.org/0000-0003-3298-0771)
- Marı́a C. Carrillo
- Casaletto Kaitlin
Institutions
- American College of Radiology (US)
- Alzheimer's Association (US)
- Kaiser Permanente (US)
- University of California, San Francisco (US)
- Virginia Commonwealth University (US)
- Washington University in St. Louis (US)
- Brown University (US)
- University of California System (US)
- Mallinckrodt (United States) (US)
- University Memory and Aging Center (US)
- Global Brain Health Institute (US)
- University of California, Davis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/alz.70304
- Citations
- 10
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 14.71
Funders
- Alzheimer's Association
- Eli Lilly and Company
- American College of Radiology
- Avid Radiopharmaceuticals