Mechanisms of Hydromorphone-Mediated Protection Against Myocardial Ischemia-Reperfusion Injury via NLRP3 Inflammasome Inhibition
Pre- or post-treatment with hydromorphone exerts protective effects against MIRI by suppressing NLRP3 inflammasomes, potentially providing a theoretical basis for its use as a therapeutic agent in MIRI patients.
Authors
- Qihua Xiong (ORCID: https://orcid.org/0000-0002-2555-4363)
- Yurong Tan (ORCID: https://orcid.org/0000-0002-0283-2105)
- Wei Xu (ORCID: https://orcid.org/0000-0002-1287-4552)
- Zhe Huang (ORCID: https://orcid.org/0000-0002-4441-0015)
- Xi Song (ORCID: https://orcid.org/0009-0005-1086-0535)
- Fuzheng Ren (ORCID: https://orcid.org/0000-0001-6531-2652)
- Qing Qi (ORCID: https://orcid.org/0000-0001-9347-3525)
- Liu Luo (ORCID: https://orcid.org/0000-0003-2075-0004)
- Shiyue Zeng
- Mingzhi Zheng
Institutions
- Central South University (CN)
- Changsha Medical University (CN)
- Zhuzhou Central Hospital (CN)
- Hunan University of Technology (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-05-01
- DOI
- https://doi.org/10.2147/jir.s509328
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00