Adjunctive beneficial effect of c-di-GMP, a STING agonist, in enhancing protective efficacy of TLR4-adjuvanted tuberculosis subunit vaccine formulations
This study highlights that CDG, when used in combination with TLR4 adjuvants, enhances long-term protective immunity, offering a promising strategy for subunit TB vaccine development.
Authors
- Sang‐Jun Ha (ORCID: https://orcid.org/0000-0002-1192-6031)
- Sung Jae Shin (ORCID: https://orcid.org/0000-0003-0854-4582)
- Hagyu Kim (ORCID: https://orcid.org/0009-0002-8770-8732)
- Kee Woong Kwon (ORCID: https://orcid.org/0000-0002-6259-855X)
- Eunsol Choi (ORCID: https://orcid.org/0000-0002-4397-5751)
- Sang‐Won Choi (ORCID: https://orcid.org/0000-0002-1603-0576)
- Hyeong-Woo Kim (ORCID: https://orcid.org/0000-0002-8588-4065)
- Seunghyun Lee (ORCID: https://orcid.org/0000-0001-9254-183X)
Institutions
- Gyeongsang National University (KR)
- Yonsei University (KR)
- Yonsei University Health System (KR)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1186/s12929-025-01144-8
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Gyeongsang National University
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea
- National Institutes of Health