LDHA-mediated YAP lactylation promotes the tumor progression of hepatocellular carcinoma by inducing YAP dephosphorylation and activation
This study highlights the significance of YAP in HCC pathogenesis, providing insights into potential therapeutic targets for HCC management.
Authors
- Ye Chen (ORCID: https://orcid.org/0009-0002-0029-8751)
- Chuan Qiu (ORCID: https://orcid.org/0000-0001-6202-9229)
- Jun Rao (ORCID: https://orcid.org/0000-0002-5089-778X)
- Yen‐Chih Huang (ORCID: https://orcid.org/0000-0001-5833-4693)
- Long Zou (ORCID: https://orcid.org/0009-0006-8554-573X)
- Guang Cheng (ORCID: https://orcid.org/0000-0002-5287-0804)
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Jiangxi Provincial Cancer Hospital (CN)
Publication Details
- Journal
- Biology Direct
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1186/s13062-025-00655-6
- Citations
- 7
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 8.06
Funders
- National Natural Science Foundation of China
- Health Commission of Jiangxi Province