Genetic variation in NSP4 of type 1 porcine reproductive and respiratory syndrome virus in China
PRRSV-1 NSP4 exhibits similarities to Subtype I Global strains and clusters into four subgroups. Although it differs from PRRSV-2 NSP4 with a deletion in the 83rd amino acid residue, the amino acid residues of the catalytic triad are conserved. These findings have important implications for the development of secure and reliable detection methods as well as new drugs and vaccines and are expected to guide further research on PRRSV-1.
Authors
- Yajie Zheng (ORCID: https://orcid.org/0000-0002-7777-2370)
- Zhiyu Yang (ORCID: https://orcid.org/0000-0002-4937-8747)
- Xiaolin Lan
- Jun Ma (ORCID: https://orcid.org/0000-0001-9955-4625)
- Weili Kong (ORCID: https://orcid.org/0000-0002-9104-7730)
- Huiyang Sha
- Qin Luo
- Mengmeng Zhao (ORCID: https://orcid.org/0000-0003-4143-3606)
- Hang Zhang (ORCID: https://orcid.org/0009-0004-6294-8208)
- Lv Chen (ORCID: https://orcid.org/0000-0001-5488-0427)
- Liangzong Huang
- Gan Li
Institutions
- Gladstone Institutes (US)
- Foshan University (CN)
Publication Details
- Journal
- BMC Veterinary Research
- Published
- 2025-05-25
- DOI
- https://doi.org/10.1186/s12917-025-04685-0
- Primary Topic
- Animal Virus Infections Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Foshan University
- National Key Research and Development Program of China