Macrophage Notch1 drives septic cardiac dysfunction by impairing mitophagy and promoting NLRP3 activation
Our study uncovers a novel role for Notch1 in exacerbating LPS-induced septic cardiac dysfunction by suppressing mitophagy in macrophages. These findings suggest that targeting Notch1 may offer a promising therapeutic strategy to mitigate sepsis-induced inflammation by restoring proper mitophagy.
Authors
- Guoqing Wan
- Jian Ma (ORCID: https://orcid.org/0000-0001-9395-0416)
- Xuefeng Gu (ORCID: https://orcid.org/0000-0002-8718-2067)
- Yanjun Zheng
- Jingrong Lin (ORCID: https://orcid.org/0000-0002-0218-7214)
Institutions
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
- Shanghai Institute of Hypertension (CN)
- Shanghai University of Medicine and Health Sciences (CN)
Publication Details
- Journal
- Biology Direct
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1186/s13062-025-00657-4
- Citations
- 3
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Shanghai Municipal Health Commission
- Science and Technology Commission of Shanghai Municipality