PSMA radioligand uptake correlates with PSMA expression in high-grade glioma and brain metastasis: insights from a prospective PET-MRI guided multiregional biopsy study
PSMA expression in brain tumours is predominately vascular, which likely explains why microvascular (rather than tumour cell) PSMA expression correlates with [<sup>68</sup>Ga]Ga-PSMA-11 uptake in HGG. This neovascular expression is crucial information for future PSMA-based RLT studies, as alpha-emitters may not sufficiently target tumour DNA. NCT05798273; date of registration: 1/9/2020.
Authors
- Sybren L. N. Maas (ORCID: https://orcid.org/0000-0002-8745-4405)
- Rutger K. Balvers (ORCID: https://orcid.org/0000-0002-6422-165X)
- Vera van Dis (ORCID: https://orcid.org/0000-0003-1824-4348)
- Thierry P. P. van den Bosch
- Sophie E. M. Veldhuijzen van Zanten (ORCID: https://orcid.org/0000-0002-3888-0977)
- Ilanah J. Pruis (ORCID: https://orcid.org/0009-0000-8427-9755)
- Marcel Segbers (ORCID: https://orcid.org/0000-0002-4866-3984)
Institutions
- DSM (Netherlands) (NL)
- Leiden University Medical Center (NL)
- Erasmus MC Cancer Institute (NL)
- Rotterdam University of Applied Sciences (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2025-05-25
- DOI
- https://doi.org/10.1007/s00259-025-07338-4
- Citations
- 5
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 7.59