Concurrent chemoradiotherapy for advanced cervical cancer during second trimester pregnancy: A case report

In Japan, pregnancies complicated by cervical cancer are rising due to the higher incidence of cervical cancer among younger women, coupled with an increase in maternal age. Evidence regarding the treatment of cervical cancer during pregnancy is limited, especially for advanced cases that cannot be managed surgically. We present a case of stage IIIC1r cervical cancer in a 30-year-old woman, in which concurrent chemoradiotherapy (CCRT) was initiated at 15 weeks of gestation, with the fetus remaining in utero. Intrauterine fetal death was confirmed on the 21st day of treatment, and the fetus was delivered at 38 days. The patient completed CCRT with minimal delay and achieved complete tumor remission, with no recurrence observed at 1 year. This case also highlights the importance of early multidisciplinary intervention.