A consortium of seven commensal bacteria promotes gut microbiota recovery and strengthens ecological barrier against vancomycin-resistant enterococci
An innovative approach based on mathematical modelling of the microbiota composition permitted to identify a mixture of commensal bacterial strains, which improves the ecological barrier effect against VRE. The mechanisms are dependent on the recovery and initial composition of the microbiota. Ultimately, this work will enable a move towards a personalised medicine by targeting predisposed patients presenting a risk of infection, such as neutropenic or bone-marrow transplant patients, and likely to respond to supplementation with commensal strains, providing new live biotherapeutic products and biomarkers to predict response to supplementation. Video Abstract.
Authors
- Nacer Mohellibi (ORCID: https://orcid.org/0000-0003-1398-6043)
- Alan Jan
- Isabelle Jouanin (ORCID: https://orcid.org/0000-0002-2344-1840)
- Clara Lemoine
- Lionel Rigottier‐Gois (ORCID: https://orcid.org/0000-0003-1561-7700)
- Fréderic Pepke
- Béatrice Laroche (ORCID: https://orcid.org/0000-0001-7821-332X)
- Marie Tremblay‐Franco (ORCID: https://orcid.org/0000-0003-4678-4456)
- Perrine Bayle
- Pascale Serror (ORCID: https://orcid.org/0000-0002-8446-9011)
- Fabienne Béguet-Crespel
Institutions
- Université Paris-Saclay (FR)
- Microbiologie de l’alimentation au service de la santé (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Centre Inria de Saclay (FR)
- Mathématiques et Informatique Appliquées du Génome à l'Environnement (FR)
Publication Details
- Journal
- Microbiome
- Published
- 2025-05-25
- DOI
- https://doi.org/10.1186/s40168-025-02127-5
- Citations
- 3
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Agence Nationale de la Recherche
- Fundació Institut de Recerca Hospital Universitari Vall d’Hebron
- Société d'Accélération du Transfert de Technologies
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement