Differentiating sporadic frontotemporal dementia from late-onset primary psychiatric disorders

Sporadic behavioural variant frontotemporal dementia (bvFTD) is often misdiagnosed as late-onset primary psychiatric disorder (PPD) due to overlapping symptoms and lack of biomarkers. We aimed to identify clinical features that distinguish sporadic bvFTD from PPD. Multi-centre baseline data were retrospectively retrieved and categorized into neuropsychological domains. Logistic regression models and receiver operating characteristic curves were conducted to determine discriminators. Data from 508 sporadic bvFTD and 152 PPD cases were included. Higher scores in cognitive screening [odds ratio (OR): 1.23], facial emotion processing (OR: 1.69), episodic memory (OR: 1.09), animal fluency (OR: 1.17), working memory (OR: 1.18), letter fluency (OR: 1.17) and depressive symptoms (OR: 7.41) were significantly associated with PPD (all <i>P</i>s ≤ 0.010). Within a combined model, higher scores of letter fluency (OR: 1.47), cognitive screening (OR: 1.72) and lower attention (OR: 0.77) were significantly (all <i>P</i>s ≤ 0.05) associated with PPD (area under the curve = 0.771). Neuropsychological measurements-letter fluency, cognitive screening and attention-can help distinguish sporadic bvFTD from late-onset PPD. Depressive symptoms and facial emotion processing emerged as potential discriminators, warranting further exploration.

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Publication Details

Journal
Brain Communications
Published
2025-01-01
DOI
https://doi.org/10.1093/braincomms/fcaf199
Citations
2
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
2.94

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article

Differentiating sporadic frontotemporal dementia from late-onset primary psychiatric disorders

Welmoed A. Krudop, Ishana Rue, Ramón Landín-Romero, Argonde C. van Harten et al.
2 citations
Brain Communications
Dementia and Cognitive Impairment Research
2.94
article

Differentiating sporadic frontotemporal dementia from late-onset primary psychiatric disorders

Welmoed A. Krudop, Ishana Rue, Ramón Landín-Romero, Argonde C. van Harten, Mardien L. Oudega, Flora H. Duits, Marie‐Paule E. van Engelen, Jay L.P. Fieldhouse, Sigfried N. T. M. Schouws, Zac Chatterton, Glenda Margaret Halliday, David Foxe, Simon Braak, Olivier Piguet, Sven J. van der Lee, James Carrick, Lina Riedl, Chiara Fenoglio, Janine Diehl‐Schmid, Daniela Galimberti, Sterre C.M. de Boer, Yolande A.L. Pijnenburg, Sophie Matis, Simon Ducharme
article en
2 citations

Abstract

Sporadic behavioural variant frontotemporal dementia (bvFTD) is often misdiagnosed as late-onset primary psychiatric disorder (PPD) due to overlapping symptoms and lack of biomarkers. We aimed to identify clinical features that distinguish sporadic bvFTD from PPD. Multi-centre baseline data were retrospectively retrieved and categorized into neuropsychological domains. Logistic regression models and receiver operating characteristic curves were conducted to determine discriminators. Data from 508 sporadic bvFTD and 152 PPD cases were included. Higher scores in cognitive screening [odds ratio (OR): 1.23], facial emotion processing (OR: 1.69), episodic memory (OR: 1.09), animal fluency (OR: 1.17), working memory (OR: 1.18), letter fluency (OR: 1.17) and depressive symptoms (OR: 7.41) were significantly associated with PPD (all <i>P</i>s ≤ 0.010). Within a combined model, higher scores of letter fluency (OR: 1.47), cognitive screening (OR: 1.72) and lower attention (OR: 0.77) were significantly (all <i>P</i>s ≤ 0.05) associated with PPD (area under the curve = 0.771). Neuropsychological measurements-letter fluency, cognitive screening and attention-can help distinguish sporadic bvFTD from late-onset PPD. Depressive symptoms and facial emotion processing emerged as potential discriminators, warranting further exploration.

Brain CommunicationsVol. 7(3)
Montreal Neurological Institute and Hospital (CA), The University of Sydney (AU), University of Milan (IT), Douglas Mental Health University Institute (CA), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT), Amsterdam Neuroscience (NL), Inn-Salzach-Klinikum (DE), GGZ inGeest (NL), Amsterdam University Medical Centers (NL), McGill University (CA), Technical University of Munich (DE), Vrije Universiteit Amsterdam (NL), Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
EU Joint Programme – Neurodegenerative Disease Research, Alzheimer Nederland, Medical Research Council, National Health and Medical Research Council
Reduced inequalities
Openalex Percentile: Top 10%
Dementia and Cognitive Impairment Research
2.94
DOIOpen Access PDFOpenAlex
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