Dermoscopy of Solitary Multinucleate Cell Angiohistiocytoma: A Rare Amelanotic Clinical Imitator of Melanoma

Multinucleate cell angiohistiocytoma (MCAH) is a rarely reported and likely underdiagnosed cutaneous entity with benign biological behavior. MCAH is described as a solitary or multiple proliferation of vascular and fibrohistiocytic origin, with largely unknown etiopathogenesis. It presents as red-brown to violaceous papules or nodules, mainly on the extremities, and is usually asymptomatic. A definitive diagnosis of MCAH requires specific histopathological and immunohistochemical findings. The following report presents a case of solitary MCAH with the aim of clarifying the clinical, histological, and especially dermoscopic aspects of this dermatological disorder, which may resemble more aggressive skin tumors.

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Journal
Cureus
Published
2025-05-25
DOI
https://doi.org/10.7759/cureus.84796
Primary Topic
Cutaneous lymphoproliferative disorders research
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article
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article

Dermoscopy of Solitary Multinucleate Cell Angiohistiocytoma: A Rare Amelanotic Clinical Imitator of Melanoma

Zannis Almpanis, Dimitrios Sgouros, George E. Sarris, Zoé Apalla
2 links
Cureus
Cutaneous lymphoproliferative disorders research
article

Dermoscopy of Solitary Multinucleate Cell Angiohistiocytoma: A Rare Amelanotic Clinical Imitator of Melanoma

Zannis Almpanis, Dimitrios Sgouros, George E. Sarris, Zoé Apalla
article en

Abstract

Multinucleate cell angiohistiocytoma (MCAH) is a rarely reported and likely underdiagnosed cutaneous entity with benign biological behavior. MCAH is described as a solitary or multiple proliferation of vascular and fibrohistiocytic origin, with largely unknown etiopathogenesis. It presents as red-brown to violaceous papules or nodules, mainly on the extremities, and is usually asymptomatic. A definitive diagnosis of MCAH requires specific histopathological and immunohistochemical findings. The following report presents a case of solitary MCAH with the aim of clarifying the clinical, histological, and especially dermoscopic aspects of this dermatological disorder, which may resemble more aggressive skin tumors.

CureusVol. 17(5)
Piedmont Athens Regional (US), National and Kapodistrian University of Athens (GR), Aristotle University of Thessaloniki (GR), University General Hospital Attikon (GR)
Zero hunger
Openalex Percentile: Top 79%
Cutaneous lymphoproliferative disorders research
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Dermoscopy of Solitary Multinucleate Cell Angiohistiocytoma: A Rare Amelanotic Clinical Imitator of Melanoma — Zannis Almpanis, Dimitrios Sgouros, et al. · Cureus (2025) | TGRS Research Map | TGRS