Fibrinogen exacerbates α-synuclein aggregation and mitochondrial dysfunction via alpha5beta3 integrin in Parkinson’s disease

Our study indicate that FG plays an essential pathological role in α-syn abnormality. FG-targeting therapy can be a promising strategy against neurodegeneration in PD.

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Publication Details

Journal
Journal of Advanced Research
Published
2025-05-25
DOI
https://doi.org/10.1016/j.jare.2025.05.050
Citations
5
Primary Topic
Parkinson's Disease Mechanisms and Treatments
Type
article
Field-Weighted Citation Impact
6.95
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article

Fibrinogen exacerbates α-synuclein aggregation and mitochondrial dysfunction via alpha5beta3 integrin in Parkinson’s disease

Zhenchao Xie, Bin Xiao, Rongfang Que, Ling Ling Chan et al.
5 citations
Journal of Advanced Research
Parkinson's Disease Mechanisms and Treatments
6.95
article

Fibrinogen exacerbates α-synuclein aggregation and mitochondrial dysfunction via alpha5beta3 integrin in Parkinson’s disease

Zhenchao Xie, Bin Xiao, Rongfang Que, Ling Ling Chan, Shuzhen Zhu, Chin‐Hsien Lin, Jialing Zheng, Jia Nee Foo, Chao Deng, Zifeng Huang, Zhidong Zhou, Weixin Zheng, Hui Zhong, Weili Yang, Feilan Yuan, Lu Zhang, Qing Wang, Wanlin Yang, Bibiao Shen, Yuqi Luo, Shuhan Chen, Kunlin Jin, Muwei Zhang, Huanzhu Liu, Eng-King Tan, Ruoyang Yu, Fen Xie
article en
5 citations

Abstract

Our study indicate that FG plays an essential pathological role in α-syn abnormality. FG-targeting therapy can be a promising strategy against neurodegeneration in PD.

Journal of Advanced ResearchVol. 81
University of North Texas (US), Jinan University (CN), University of North Texas Health Science Center (US), Nanyang Technological University (SG), University of Macau (MO), University of Wollongong (AU), Singapore General Hospital (SG), Guangzhou Experimental Station (CN), Zhujiang Hospital (CN), Duke-NUS Medical School (SG), National Neuroscience Institute (SG), National Taiwan University Hospital (TW), Southern Medical University (CN)
Zero hunger
Openalex Percentile: Top 3%
Parkinson's Disease Mechanisms and Treatments
6.95
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