Fibrinogen exacerbates α-synuclein aggregation and mitochondrial dysfunction via alpha5beta3 integrin in Parkinson’s disease
Our study indicate that FG plays an essential pathological role in α-syn abnormality. FG-targeting therapy can be a promising strategy against neurodegeneration in PD.
Authors
- Zhenchao Xie
- Bin Xiao (ORCID: https://orcid.org/0000-0003-2986-4980)
- Rongfang Que (ORCID: https://orcid.org/0000-0002-2331-2563)
- Ling Ling Chan (ORCID: https://orcid.org/0000-0001-7603-7334)
- Shuzhen Zhu (ORCID: https://orcid.org/0000-0002-2514-1809)
- Chin‐Hsien Lin (ORCID: https://orcid.org/0000-0001-8566-7573)
- Jialing Zheng (ORCID: https://orcid.org/0000-0003-2400-7103)
- Jia Nee Foo (ORCID: https://orcid.org/0000-0001-9899-2308)
- Chao Deng (ORCID: https://orcid.org/0000-0003-1147-5741)
- Zifeng Huang (ORCID: https://orcid.org/0000-0002-1199-291X)
- Zhidong Zhou (ORCID: https://orcid.org/0000-0003-0251-4163)
- Weixin Zheng (ORCID: https://orcid.org/0000-0002-7541-3681)
- Hui Zhong (ORCID: https://orcid.org/0000-0002-6909-6456)
- Weili Yang (ORCID: https://orcid.org/0000-0001-6830-5204)
- Feilan Yuan
- Lu Zhang (ORCID: https://orcid.org/0000-0001-7141-6730)
- Qing Wang (ORCID: https://orcid.org/0000-0002-3882-6540)
- Wanlin Yang
- Bibiao Shen
- Yuqi Luo (ORCID: https://orcid.org/0009-0003-4221-009X)
- Shuhan Chen
- Kunlin Jin (ORCID: https://orcid.org/0009-0008-6668-7438)
- Muwei Zhang
- Huanzhu Liu
- Eng-King Tan
- Ruoyang Yu
- Fen Xie
Institutions
- University of North Texas (US)
- Jinan University (CN)
- University of North Texas Health Science Center (US)
- Nanyang Technological University (SG)
- University of Macau (MO)
- University of Wollongong (AU)
- Singapore General Hospital (SG)
- Guangzhou Experimental Station (CN)
- Zhujiang Hospital (CN)
- Duke-NUS Medical School (SG)
- National Neuroscience Institute (SG)
- National Taiwan University Hospital (TW)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-05-25
- DOI
- https://doi.org/10.1016/j.jare.2025.05.050
- Citations
- 5
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.95