Intra-aortic infusion of nicotine can induce a novel mouse model of abdominal aortic aneurysm
In this study, we established a novel and highly efficient experimental AAA model via direct intraluminal nicotine infusion. We also demonstrated that nicotine-induced AAA formation is partially dependent on the activation of its receptors, thus providing a research tool for studying the management of smoking-induced AAAs.
Authors
- Haiwen Hou
- Enqi Liu (ORCID: https://orcid.org/0000-0002-2092-3158)
- F MALIK (ORCID: https://orcid.org/0009-0003-4937-189X)
- Yibin Meng (ORCID: https://orcid.org/0000-0003-0173-2740)
- Haole Liu
- Baohui Xu (ORCID: https://orcid.org/0000-0002-2857-7464)
- Panpan Wei
- Kangli Tian
- Kexin Li (ORCID: https://orcid.org/0009-0001-7193-0534)
- Sihai Zhao (ORCID: https://orcid.org/0000-0002-5845-6639)
- Le Qin (ORCID: https://orcid.org/0000-0002-8244-8217)
- Jiawei Zou (ORCID: https://orcid.org/0000-0003-1549-0340)
- Congcong Xia
- Tianzhi Cai
- Runyu Tian
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Xi'an Jiaotong University (CN)
- Stanford University (US)
Publication Details
- Journal
- European Journal of Pharmaceutical Sciences
- Published
- 2025-05-25
- DOI
- https://doi.org/10.1016/j.ejps.2025.107143
- Primary Topic
- Aortic aneurysm repair treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shaanxi Province