FAM172A deletion aggravates high fat diet-induced MASLD via the eIF2α-ATF4-FGF21 loop
Fam172a gene deletion can promote HFD-induced MASLD via the eIF2α-ATF4 pathway. The expression of Fgf21, up-regulated by the eIF2α-ATF4 pathway, partially inhibit the effects of Fam172a gene deletion via negative feedback loop. Thus, FAM172A may serve as a potential target of MASLD.
Authors
- Zhe Yu (ORCID: https://orcid.org/0000-0002-6841-1725)
- Shiwei Wang
- Hongshan Wei (ORCID: https://orcid.org/0000-0001-8893-653X)
- Herui Wei
- Junru Yang (ORCID: https://orcid.org/0000-0003-4030-7560)
- Mengqi Li (ORCID: https://orcid.org/0000-0002-8083-9142)
- Fan Xiao (ORCID: https://orcid.org/0009-0006-5265-5174)
- Meixin Gao
Institutions
- Beijing Tongren Hospital (CN)
- Capital Medical University (CN)
- Peking University (CN)
- Peking University People's Hospital (CN)
- Beijing Ditan Hospital (CN)
Publication Details
- Journal
- Life Sciences
- Published
- 2025-05-25
- DOI
- https://doi.org/10.1016/j.lfs.2025.123763
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Youth Foundation
- National Natural Science Foundation of China
- National Outstanding Youth Science Fund Project of National Natural Science Foundation of China