Prevalence of multiple myeloma in patients on hemodialysis programs

Introduction: Multiple myeloma (MM) is a hematological malignancy that often causes kidney failure, affecting more than 50% of MM patients. Kidney damage in MM is primarily due to cast nephropathy, light chain deposition disease, and amyloidosis. However, there are no data on MM patients undergoing hemodialysis in Ecuador. This study aims to report the prevalence of MM in the country's hemodialysis units. Methods: This observational, descriptive, cross-sectional, multicenter study evaluated the prevalence of MM in hemodialysis patients in Ecuador. A survey was distributed to 23 nephrologists, collecting data on the total number of hemodialysis patients and those diagnosed with MM. Prevalence was calculated using the formula: Prevalence = (MM patients / Total hemodialysis patients) × 1000. Data were analyzed using nonparametric methods in R v4.3.2, with 99% confidence intervals. Results: were diagnosed with MM, yielding a prevalence of 1.1% (95% CI: 0.7% to 1.6%), or 11.3 cases per 1000 hemodialysis patients. The number of MM cases varied by city, with the highest number reported in Portoviejo (10 cases) and none in Riobamba. Conclusion: The prevalence of MM in Ecuador is consistent with international reports, with similar findings in the United States (1.0%), Nigeria (0.81%), and other Latin American countries. These findings highlight the need for a national registry to better understand the needs of MM patients on hemodialysis.

Authors

Institutions

Publication Details

Journal
Revista de la Sociedad Ecuatoriana de Nefrología Diálisis y Trasplante
Published
2025-03-16
DOI
https://doi.org/10.56867/106
Primary Topic
Pharmacological Effects and Toxicity Studies
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Prevalence of multiple myeloma in patients on hemodialysis programs

David Garrido, Sandra Valarezo, Jorge Huertas, Washington Osorio et al.
Revista de la Sociedad Ecuatoriana de Nefrología Diálisis y Trasplante
Pharmacological Effects and Toxicity Studies
article

Prevalence of multiple myeloma in patients on hemodialysis programs

David Garrido, Sandra Valarezo, Jorge Huertas, Washington Osorio, Ubelis Rosales, Juan Cristóbal Santacruz Mancheno, Juan Carlos Pérez Chil, Omar Seminario, Franklin Mora‐Bravo, Rosalina De Lourdes Lituma Jumbo, Santiago Silva, Nicolle Rodriguez, Greysi Virla, Isabel Leon Baquero, Ailiyomar Perez, A Quevedo, Víctor Hugo Ortega, James Muñoz, Alfonso Silva Contreras, Daniel Arias, Juan Carlos Paz, Evelyn Moreira, J. F. Moscoso, Cristhian Mejía, Willan Patricio Robles Abarca
article en

Abstract

Introduction: Multiple myeloma (MM) is a hematological malignancy that often causes kidney failure, affecting more than 50% of MM patients. Kidney damage in MM is primarily due to cast nephropathy, light chain deposition disease, and amyloidosis. However, there are no data on MM patients undergoing hemodialysis in Ecuador. This study aims to report the prevalence of MM in the country's hemodialysis units. Methods: This observational, descriptive, cross-sectional, multicenter study evaluated the prevalence of MM in hemodialysis patients in Ecuador. A survey was distributed to 23 nephrologists, collecting data on the total number of hemodialysis patients and those diagnosed with MM. Prevalence was calculated using the formula: Prevalence = (MM patients / Total hemodialysis patients) × 1000. Data were analyzed using nonparametric methods in R v4.3.2, with 99% confidence intervals. Results: were diagnosed with MM, yielding a prevalence of 1.1% (95% CI: 0.7% to 1.6%), or 11.3 cases per 1000 hemodialysis patients. The number of MM cases varied by city, with the highest number reported in Portoviejo (10 cases) and none in Riobamba. Conclusion: The prevalence of MM in Ecuador is consistent with international reports, with similar findings in the United States (1.0%), Nigeria (0.81%), and other Latin American countries. These findings highlight the need for a national registry to better understand the needs of MM patients on hemodialysis.

Revista de la Sociedad Ecuatoriana de Nefrología Diálisis y TrasplanteVol. 13(2)
Universidad Nacional Experimental Simón Rodríguez (VE), Renal Association (GB), Hospital Universitario de San Vicente Fundación (CO), Universidad de las Américas (NI), Universidad Estatal de Milagro (EC), Mentor (GB), Hospital Militar Principal (PT), Universidad de Las Américas (EC), Private University of Trujillo (PE), Hospital Militar Central (CO), Hospital Oncológico Docente "Conrado Benítez García" (CU), Hospital São Vicente (BR), Facultad Latinoamericana de Ciencias Ecuador (EC), Ministerio de Salud Pública (EC), Clínica Santa María (CO), Fresenius Medical Care (United States) (US), Universidad Técnica de Ambato (EC), Hospital Central de las Fuerzas Armadas (UY), Hospital de Clínicas (UY), Baxter (United States) (US)
Openalex Percentile: Top 84%
Pharmacological Effects and Toxicity Studies
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.