Pulse Pressure, White Matter Hyperintensities, and Cognition: Mediating Effects Across the Adult Lifespan
Our results indicate that pulse pressure, but not mean arterial pressure, is mechanistically associated with age-related accumulation of white matter hyperintensities, independent of other cardiovascular risk factors. White matter hyperintensity load was a mediator of cognitive scores across the adult lifespan. Effective management of pulse pressure may be especially important for maintenance of brain health and cognition.
Authors
- Julius Fridriksson (ORCID: https://orcid.org/0000-0001-9255-2045)
- Natalie Busby (ORCID: https://orcid.org/0000-0001-7117-7899)
- Jade Hannan (ORCID: https://orcid.org/0000-0003-2815-9905)
- Roger Newman‐Norlund (ORCID: https://orcid.org/0000-0002-0966-1070)
- Sarah Newman‐Norlund (ORCID: https://orcid.org/0000-0002-9064-1332)
- Leonardo Bonilha (ORCID: https://orcid.org/0000-0002-6153-8942)
- Sarah Wilson (ORCID: https://orcid.org/0000-0002-5559-4569)
- Chris Rorden (ORCID: https://orcid.org/0000-0002-7554-6142)
- Nicholas Riccardi (ORCID: https://orcid.org/0000-0001-7243-6100)
Institutions
- University of South Carolina (US)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2025-05-25
- DOI
- https://doi.org/10.1002/acn3.70086
- Citations
- 6
- Primary Topic
- Cardiovascular Health and Disease Prevention
- Type
- article
- Field-Weighted Citation Impact
- 8.33
Funders
- University of South Carolina
- National Institutes of Health
- National Institute of Mental Health
- National Institute on Deafness and Other Communication Disorders