Updated efficacy and safety of CDK4/6 inhibitors plus endocrine therapy in elderly women with HR+/HER-2 metastatic or advanced breast cancer: patient-level network meta-analysis

In this network meta-analysis, the combination of Palbociclib with Letrozole or Fulvestrant was found to have an effect on PFS and OS, and Ribociclib + Let was found to be a relatively safe treatment option for elderly women with HR+/HER2 metastatic or advanced BC. However, given the limited evidence in older populations, comprehensive, well-designed, large-scale randomized controlled trials are needed to address this issue.