Multidirectional therapeutic effects of synthesized HMGB1 peptide on liver cirrhosis in mice
Over time, macrophages followed by HSCs, showed the most notable changes with treatment, resulting in improved fibrosis. The HMGB1 peptide drug also affected lipid metabolism in hepatocytes, suggesting a positive therapeutic effect on steatohepatitis. Elevated factors that promote cell migration may have also enhanced the healing effect.
Authors
- Kenichiro Furuyama (ORCID: https://orcid.org/0000-0003-4878-2841)
- Nobutaka Takeda
- Shuji Terai (ORCID: https://orcid.org/0000-0002-5439-635X)
- T Tonouchi
- Atsunori Tsuchiya (ORCID: https://orcid.org/0000-0002-9279-5917)
- Soichi Ishii
- Masaki Mito (ORCID: https://orcid.org/0000-0002-4911-9745)
- Katsuto Tamai (ORCID: https://orcid.org/0000-0003-0953-7157)
- Ryo Jinbo
- Hiroyuki Abe
Institutions
- Niigata University Medical and Dental Hospital (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Biochemistry and Biophysics Reports
- Published
- 2025-05-25
- DOI
- https://doi.org/10.1016/j.bbrep.2025.102061
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shionogi